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Vitamin D Metabolism Genes Are Differentially Methylated in Individuals with Chronic Knee Pain.
- Source :
-
Lifestyle genomics [Lifestyle Genom] 2023; Vol. 16 (1), pp. 98-105. Date of Electronic Publication: 2023 Feb 28. - Publication Year :
- 2023
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Abstract
- Introduction: Recent evidence suggests that vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an adequate level of vitamin D present, made possible by enzymatic reactions that allow vitamin D to be biologically active. The purpose of this study was to explore the epigenetic landscape of genes involved in vitamin D metabolism in individuals with and without chronic knee pain.<br />Methods: Community-dwelling individuals recruited as part of a larger study focused on knee pain provided demographic, clinical, and pain-related information, as well as an intravenous blood sample to determine DNA methylation levels at CpG sites.<br />Results: There were differences in DNA methylation between those with and without pain in genes that code for enzymes related to vitamin D metabolism: CYP27B1 (1-α-hydroxylase). There was also hypermethylation on the gene that codes for the vitamin D receptor (VDR).<br />Conclusions: The presence of chronic pain is associated with epigenetic modifications in genes responsible for the expression of enzymes involved in vitamin D metabolism and cellular function. These results lay groundwork in understanding the mechanism underlying the association between vitamin D and chronic pain.<br /> (© 2023 The Author(s). Published by S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 2504-3188
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lifestyle genomics
- Publication Type :
- Academic Journal
- Accession number :
- 36854277
- Full Text :
- https://doi.org/10.1159/000529823