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A Retrospective Analysis of Risk Factors and Impact of Acute Kidney Injury in Critically Ill Children.
- Source :
-
Klinische Padiatrie [Klin Padiatr] 2024 Jul; Vol. 236 (4), pp. 229-239. Date of Electronic Publication: 2023 Feb 27. - Publication Year :
- 2024
-
Abstract
- Background: Acute kidney injury (AKI) is a serious clinical condition in critically ill children and is associated with worse outcomes. A few pediatric studies focused on the risk factors of AKI. We aimed to identify the incidence, risk factors, and outcomes of AKI in the pediatric intensive care unit (PICU).<br />Patients and Methods: All the patients admitted to PICU over a period of 20 months were included. We compared both groups the risk factors between AKI and non-AKI.<br />Results: A total of 63 patients (17.5%) of the 360 patients developed AKI during PICU stay. The presence of comorbidity, diagnosis of sepsis, increased PRISM III score, and positive renal angina index were found to be risk factors for AKI on admission. Thrombocytopenia, multiple organ failure syndrome, the requirement of mechanical ventilation, use of inotropic drugs, intravenous iodinated contrast media, and exposure to an increased number of nephrotoxic drugs were independent risk factors during the hospital stay. The patients with AKI had a lower renal function on discharge and had worse overall survival.<br />Conclusions: AKI is prevalent and multifactorial in critically sick children. The risk factors of AKI may be present on admission and during the hospital stay. AKI is related to prolonged mechanical ventilation days, longer PICU stays, and a higher mortality rate. Based on the presented results early prediction of AKI and consequent modification of nephrotoxic medication may generate positive effects on the outcome of critically ill children.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
- Subjects :
- Humans
Risk Factors
Female
Male
Child
Child, Preschool
Retrospective Studies
Infant
Respiration, Artificial
Adolescent
Comorbidity
Multiple Organ Failure mortality
Multiple Organ Failure diagnosis
Multiple Organ Failure etiology
Hospital Mortality
Sepsis complications
Sepsis epidemiology
Sepsis mortality
Germany
Acute Kidney Injury epidemiology
Acute Kidney Injury mortality
Acute Kidney Injury diagnosis
Acute Kidney Injury therapy
Critical Illness
Intensive Care Units, Pediatric
Length of Stay
Subjects
Details
- Language :
- English
- ISSN :
- 1439-3824
- Volume :
- 236
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Klinische Padiatrie
- Publication Type :
- Academic Journal
- Accession number :
- 36848938
- Full Text :
- https://doi.org/10.1055/a-1996-1761