Back to Search Start Over

VISTA H-Score Is Significantly Associated with a 5-Year DFS Rate in Oral Squamous Cell Carcinoma.

Authors :
Starzyńska A
Sobocki BK
Sakowicz-Burkiewicz M
Jereczek-Fossa BA
Alterio D
Szot O
Korwat A
Pęksa R
Source :
Journal of clinical medicine [J Clin Med] 2023 Feb 17; Vol. 12 (4). Date of Electronic Publication: 2023 Feb 17.
Publication Year :
2023

Abstract

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in the world. Despite its prevalence, it is often recognized in advanced stages (III or IV) when it has already spread to local lymph nodes. In this study, we investigate the V-domain Ig suppressor of T cell activation (VISTA) as a potential prognostic factor in OSCC. Tissue samples were collected from 71 oral squamous cell carcinoma patients to determine protein expression levels (using immunochemistry and the semi-quantitative H-score method). Moreover, RT-qPCR was additionally performed in 35 patients. Clinical factors in our cohort study had no impact on VISTA expression. However, VISTA expression is largely correlated with Il-33 levels in tumor cells and lymphocytes and with PD-L1 in tumor cells. The impact of VISTA expression on overall survival (OS) is rather limited, but in the case of a 5-year survival rate, a significant association has been proven. VISTA seems to be a rather weak clinicopathological marker but needs further evaluation in the context of survival. In addition, the potential of VISTA combination with Il-33 or PD-L1 should be further investigated in OSCC.

Details

Language :
English
ISSN :
2077-0383
Volume :
12
Issue :
4
Database :
MEDLINE
Journal :
Journal of clinical medicine
Publication Type :
Academic Journal
Accession number :
36836154
Full Text :
https://doi.org/10.3390/jcm12041619