The longevity protein p66 Shc is required for neonatal heart regeneration.

Authors :: Huang C
Ding T
Zhang Y
Li X
Sun X
Lv S
Hao Y
Bai L
Liu N
Xie Y
Chen H
Nie Y
Source :: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2023 Apr; Vol. 177, pp. 21-27. Date of Electronic Publication: 2023 Feb 22.
Publication Year :: 2023
Abstract: The longevity protein p66 <superscript>Shc</superscript> is essential for the senescence signaling that is involved in heart regeneration and remodeling. However, the exact role of p66 <superscript>Shc</superscript> in heart regeneration is unknown. In this study, we found that p66 <superscript>Shc</superscript> deficiency decreased neonatal mouse cardiomyocyte (CM) proliferation and impeded neonatal heart regeneration after apical resection injury. RNA sequencing and functional verification demonstrated that p66 <superscript>Shc</superscript> regulated CM proliferation by activating β-catenin signaling. These findings reveal the critical role of p66 <superscript>Shc</superscript> in neonatal heart regeneration and provide new insights into senescence signaling in heart regeneration.<br />Competing Interests: Declaration of Competing Interest There are no conflicts of interest to disclose.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)