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Copper-Catalyzed Oxidative [1+2+1+2] Cascade Cyclization of N,N-Dimethyl Enaminones with Benzylamines: A Facile Access to Functionalized 1,4-Dihydropyridines.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 May 16; Vol. 29 (28), pp. e202300297. Date of Electronic Publication: 2023 Mar 28. - Publication Year :
- 2023
-
Abstract
- Using benzylamines as the C4 source of 1,4-dihydropyridines (1,4-DHPs), a Cu-catalyzed oxidative [1+2+1+2] cascade cyclization for the synthesis of 1,4-DHPs was firstly developed. A broad range of easily available N,N-dimethyl enaminones and benzylamines are employed smoothly to provide a diverse range of 1,4-DHPs with high efficiency. This method is performed by a one-pot cascade C(sp <superscript>3</superscript> )-H bond functionalization/C(sp <superscript>3</superscript> )-N cleavage/cyclization strategy to form simultaneously two C(sp <superscript>3</superscript> )-C(sp <superscript>2</superscript> ) bonds, two C(sp <superscript>2</superscript> )-N bonds, and a 1,4-DHP ring.<br /> (© 2023 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 29
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 36825432
- Full Text :
- https://doi.org/10.1002/chem.202300297