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Adult height and health-related quality of life in patients born small for gestational age treated with recombinant growth hormone.
- Source :
-
Scientific reports [Sci Rep] 2023 Feb 23; Vol. 13 (1), pp. 3135. Date of Electronic Publication: 2023 Feb 23. - Publication Year :
- 2023
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Abstract
- Health related quality of life (HRQoL) is a relevant result when assessing the course of different pathologies and the efficacy of their treatments. HRQoL has been studied previously on adults born small for gestational age (SGA), both in the general population and in patients who had received recombinant human growth hormone (rhGH) treatment, with disparate results. Our study included 50 adults who had received rhGH treatment for the SGA indication in 4 Spanish hospitals. Data have been gathered retrospectively from their clinical records, current weight and height were measured, and patients have been asked to fill out SF-36 and QoLAGHDA quality of life forms, and the Graffar test to evaluate their socio-economical status. Patient's adult height was - 1.2 ± 0.9 SD, lower than their target height of 1 ± 0.8 SD, but gaining 1.7 ± 1 SD from the beginning of the treatment. SF-36 test results showed lower scoring on Mental Health domains than on those related to Physical Health. No correlation was found between HRQoL results and final height, rhGH treatment duration or puberty. Correlation was indeed found between QoLAGHDA and several domains of SF-36, but QoLAGHDA detected fewer patients with low HRQoL than SF-36. Thus, it is concluded that SGA patient's follow-up should include a HRQoL, neuro-cognitive and psychiatric assessment in their transition to adult age. Adult SGA patients without catch up growth have impaired HRQoL, especially in mental health domains.<br /> (© 2023. The Author(s).)
- Subjects :
- Adult
Humans
Infant, Newborn
Recombinant Proteins therapeutic use
Retrospective Studies
Body Height drug effects
Human Growth Hormone therapeutic use
Infant, Small for Gestational Age growth & development
Infant, Small for Gestational Age psychology
Quality of Life
Growth Disorders drug therapy
Growth Disorders etiology
Growth Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 36823445
- Full Text :
- https://doi.org/10.1038/s41598-023-30281-z