MicroED in drug discovery.

Authors :: Danelius E
Patel K
Gonzalez B
Gonen T
Source :: Current opinion in structural biology [Curr Opin Struct Biol] 2023 Apr; Vol. 79, pp. 102549. Date of Electronic Publication: 2023 Feb 21.
Publication Year :: 2023
Abstract: The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in structural biology, MicroED provides many advantages deriving from the use of nanocrystalline material for the investigations. Here, we review the recent advancements in the field of MicroED and show important examples of small molecule, peptide and protein structures that has contributed to the current development of this method as an important tool for drug discovery.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)