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Regarding Kaya P et al. "Predictive Factors for the Prognosis of Vogt-Koyanagi-Harada Disease".

Authors :
Ruiz-Lozano RE
Rodriguez-Garcia A
Source :
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 Oct; Vol. 31 (8), pp. 1736-1737. Date of Electronic Publication: 2023 Feb 23.
Publication Year :
2023

Abstract

Introduction: VKH is a primary stromal choroiditis. Studies with indocyanine green angiography (ICGA) have shown that inflammation begins at the choroid and may persist without clinically apparent inflammation. Thus, systemic therapy must target choroidal inflammation and be maintained until the choroiditis resolves, as proven by ICG and/or EDI-OCT imaging studies.<br />Discussion: Aggressive therapy with oral corticosteroids, with or without "pulsed" intravenous methylprednisolone, has been the mainstay of VKH therapy in the acute phase for many years. However, there is convincing evidence that corticosteroid monotherapy is insufficient to prevent progression onto the chronic recurrent form of the disease, which is associated with poor visual outcomes.<br />Conclusion: Numerous studies suggest that combined therapy with systemic corticosteroids and immunosuppressants is necessary to prevent the progression toward chronic recurrent disease, avoiding complications, get a better control of inflammation and visual outcomes in VKH patients seen at the uveitic phase of the disease.

Details

Language :
English
ISSN :
1744-5078
Volume :
31
Issue :
8
Database :
MEDLINE
Journal :
Ocular immunology and inflammation
Publication Type :
Academic Journal
Accession number :
36821377
Full Text :
https://doi.org/10.1080/09273948.2023.2179500