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Cellular senescence: when growth stimulation meets cell cycle arrest.
- Source :
-
Aging [Aging (Albany NY)] 2023 Feb 19; Vol. 15 (4), pp. 905-913. Date of Electronic Publication: 2023 Feb 19. - Publication Year :
- 2023
-
Abstract
- At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.
- Subjects :
- Cell Cycle Checkpoints genetics
Cell Proliferation
Cellular Senescence genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 36805938
- Full Text :
- https://doi.org/10.18632/aging.204543