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MUM-1 in canine lymphoma: A pilot study.
- Source :
-
Veterinary pathology [Vet Pathol] 2023 May; Vol. 60 (3), pp. 316-319. Date of Electronic Publication: 2023 Feb 17. - Publication Year :
- 2023
-
Abstract
- Expression of interferon regulatory factor 4 (IRF4)/multiple myeloma oncogene-1 (MUM1) in peripheral T-cell lymphoma (PTCL) in people is associated with a poorer survival outcome compared to cases of PTCL lacking MUM1 expression. The aim of this study was to determine whether MUM1 is expressed in canine peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). For comparison, the presence of MUM1 antigen was also investigated in canine diffuse large B cell lymphoma (DLBCL). Nine cases of PTCL-NOS and 9 cases of DLBCL diagnosed by a commercial veterinary diagnostic laboratory were selected. Positive immunohistochemical labeling for MUM1 was observed in PTCL-NOS (2 out of 9 cases) and DLBCL (3 out of 9 cases). These findings suggest that a subset of neoplastic T and B lymphocytes can express MUM1. The role of MUM1 in the biological behavior and outcome of canine lymphoma (CL) requires further investigation on a larger number of cases.
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 36800915
- Full Text :
- https://doi.org/10.1177/03009858231155401