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microRNA-128-3p inhibits proliferation and accelerates apoptosis of gastric cancer cells via inhibition of TUFT1.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2023 Feb 17; Vol. 21 (1), pp. 47. Date of Electronic Publication: 2023 Feb 17. - Publication Year :
- 2023
-
Abstract
- Objective: Gastric cancer (GC) is a malignant tumor rooting in the gastric mucosal epithelium, ranking the first among various malignant tumors. Therefore, the influence of microRNA-128-3p (miR-128-3p) by regulation of Tuftelin1 (TUFT1) on GC cells was investigated.<br />Methods: The expression levels of miR-128-3p and TUFT1 in GC tissues and cells were detected. The correlation between miR-128-3p expression and overall survival of GC patients was analyzed. Human GC cells MGC803 were transfected with miR-128-3p or TUFT1-related oligonucleotides to figure their roles in viability, apoptosis, invasion, as well as epithelial-mesenchymal transition (EMT). The relationship between miR-128-3p and TUFT1 was validated.<br />Results: miR-128-3p expression was low and TUFT1 expression was high in GC tissues. miR-128-3p expression was positively correlated with the overall survival of patients with GC. miR-128-3p targeted TUFT1. Up-regulated miR-128-3p or suppressed TUFT1 repressed viability, invasion, and EMT, and accelerated apoptosis of GC cells. Overexpressed TUFT1 reduced miR-128-3p-mediated growth inhibition of GC cells.<br />Conclusion: The study stresses that miR-128-3p can inhibit TUFT1 expression, thereby repressing GC cell activities.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 36797791
- Full Text :
- https://doi.org/10.1186/s12957-023-02906-0