Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum.

Authors :: Zhan R
Zhang XY
Li ZY
Liu B
Chen YG
Source :: Chemistry & biodiversity [Chem Biodivers] 2023 Mar; Vol. 20 (3), pp. e202201185. Date of Electronic Publication: 2023 Mar 02.
Publication Year :: 2023
Abstract: Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1-9 were specifically immunosuppressive to T lymphocytes with IC <subscript>50</subscript> values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC <subscript>50</subscript> =1.62 μM) and 2 (IC <subscript>50</subscript> =0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.<br /> (© 2023 Wiley-VHCA AG, Zurich, Switzerland.)