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Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and i n vitro evaluation.
- Source :
-
Therapeutic delivery [Ther Deliv] 2023 Feb 07. Date of Electronic Publication: 2023 Feb 07. - Publication Year :
- 2023
- Publisher :
- Ahead of Print
-
Abstract
- Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & methods: The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer. Results: SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. In vitro studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles. Conclusion: Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation.
Details
- Language :
- English
- ISSN :
- 2041-6008
- Database :
- MEDLINE
- Journal :
- Therapeutic delivery
- Publication Type :
- Academic Journal
- Accession number :
- 36748662
- Full Text :
- https://doi.org/10.4155/tde-2022-0043