Triterpenoids from the leaves of Abies koreana and their biological activities.

Authors :: Lee DJ
Hong SM
Yoon DH
Ham SL
Kim J
Kim SY
Choi SU
Kim CS
Lee KR
Source :: Phytochemistry [Phytochemistry] 2023 Apr; Vol. 208, pp. 113594. Date of Electronic Publication: 2023 Feb 03.
Publication Year :: 2023
Abstract: Seven undescribed triterpenoids, abikoranes A-G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC <subscript>50</subscript> 0.89-9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC <subscript>50</subscript> values of 11.57-15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)