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Nascent Geographic Atrophy as a Predictor of Type 3 Macular Neovascularization Development.

Authors :
Sacconi R
Sarraf D
Sadda SR
Freund KB
Servillo A
Fogel Levin MM
Costanzo E
Corradetti G
Cabral D
Zur D
Trivizki O
Parravano M
Bandello F
Loewenstein A
Querques G
Source :
Ophthalmology. Retina [Ophthalmol Retina] 2023 Jul; Vol. 7 (7), pp. 586-592. Date of Electronic Publication: 2023 Feb 02.
Publication Year :
2023

Abstract

Purpose: To investigate the association of nascent geographic atrophy (GA) preceding the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD).<br />Design: Retrospective longitudinal study.<br />Participants: Patients with AMD diagnosed with treatment-naive exudative type 3 MNV in 1 or both eyes were evaluated. Inclusion criteria included serial tracked structural OCT examinations for ≥ 2 years before the detection of exudative type 3 MNV.<br />Methods: Clinical characteristics and retinal imaging, including structural OCT at baseline and at each follow-up examination, were analyzed. Eyes showing the presence of nascent GA during the follow-up were selected for analysis of prevalence, and clinical characteristics at the site of subsequent type 3 MNV development.<br />Main Outcome Measures: Description of the prevalence and clinical characteristics of nascent GA at the site of subsequent type 3 MNV development.<br />Results: Overall, 97 eyes affected by type 3 MNV meeting inclusion criteria were analyzed. Of 97 eyes (71 patients), 22 eyes of 21 patients (mean age 82 ± 9 years) showed nascent GA preceding exudative type 3 MNV. The observed prevalence of nascent GA preceding exudative type 3 MNV was 22.7% (95% confidence interval, 14.4%-31.0%). Exudative type 3 MNV developed a mean of 9 ± 6 months after detection of nascent GA. The presence of reticular pseudodrusen in the study eye did not significantly influence the timing of exudative type 3 MNV development after the observation of nascent GA (P > 0.1 in all analyses). Reduced best-corrected visual acuity was recorded at the exudative type 3 stage in comparison with the nascent GA stage (P = 0.003).<br />Conclusions: As nascent GA may precede the development of exudative type 3 MNV, the detection of nascent GA in eyes with AMD may warrant closer surveillance to identify early exudative type 3 MNV warranting treatment.<br />Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.<br /> (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2468-6530
Volume :
7
Issue :
7
Database :
MEDLINE
Journal :
Ophthalmology. Retina
Publication Type :
Academic Journal
Accession number :
36736896
Full Text :
https://doi.org/10.1016/j.oret.2023.01.019