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Nascent Geographic Atrophy as a Predictor of Type 3 Macular Neovascularization Development.
- Source :
-
Ophthalmology. Retina [Ophthalmol Retina] 2023 Jul; Vol. 7 (7), pp. 586-592. Date of Electronic Publication: 2023 Feb 02. - Publication Year :
- 2023
-
Abstract
- Purpose: To investigate the association of nascent geographic atrophy (GA) preceding the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD).<br />Design: Retrospective longitudinal study.<br />Participants: Patients with AMD diagnosed with treatment-naive exudative type 3 MNV in 1 or both eyes were evaluated. Inclusion criteria included serial tracked structural OCT examinations for ≥ 2 years before the detection of exudative type 3 MNV.<br />Methods: Clinical characteristics and retinal imaging, including structural OCT at baseline and at each follow-up examination, were analyzed. Eyes showing the presence of nascent GA during the follow-up were selected for analysis of prevalence, and clinical characteristics at the site of subsequent type 3 MNV development.<br />Main Outcome Measures: Description of the prevalence and clinical characteristics of nascent GA at the site of subsequent type 3 MNV development.<br />Results: Overall, 97 eyes affected by type 3 MNV meeting inclusion criteria were analyzed. Of 97 eyes (71 patients), 22 eyes of 21 patients (mean age 82 ± 9 years) showed nascent GA preceding exudative type 3 MNV. The observed prevalence of nascent GA preceding exudative type 3 MNV was 22.7% (95% confidence interval, 14.4%-31.0%). Exudative type 3 MNV developed a mean of 9 ± 6 months after detection of nascent GA. The presence of reticular pseudodrusen in the study eye did not significantly influence the timing of exudative type 3 MNV development after the observation of nascent GA (P > 0.1 in all analyses). Reduced best-corrected visual acuity was recorded at the exudative type 3 stage in comparison with the nascent GA stage (P = 0.003).<br />Conclusions: As nascent GA may precede the development of exudative type 3 MNV, the detection of nascent GA in eyes with AMD may warrant closer surveillance to identify early exudative type 3 MNV warranting treatment.<br />Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.<br /> (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Aged
Aged, 80 and over
Retrospective Studies
Longitudinal Studies
Fluorescein Angiography methods
Fundus Oculi
Geographic Atrophy diagnosis
Macular Degeneration diagnosis
Choroidal Neovascularization diagnosis
Choroidal Neovascularization epidemiology
Choroidal Neovascularization drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2468-6530
- Volume :
- 7
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Ophthalmology. Retina
- Publication Type :
- Academic Journal
- Accession number :
- 36736896
- Full Text :
- https://doi.org/10.1016/j.oret.2023.01.019