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Self-Assembled Core-Shell Nanoscale Coordination Polymer Nanoparticles Carrying a Sialyltransferase Inhibitor for Cancer Metastasis Inhibition.

Authors :
Zhang X
Xu CH
Mo J
Zheng XJ
Chen YF
Yang AQ
Zhang YH
Wang PY
Yuan X
Ye XS
Source :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Feb 15; Vol. 15 (6), pp. 7713-7724. Date of Electronic Publication: 2023 Feb 02.
Publication Year :
2023

Abstract

Despite hypersialylation of cancer cells together with a significant upregulation of sialyltransferase (ST) activity contributes to the metastatic cascade at multiple levels, there are few dedicated tools to interfere with their expression. Although transition state-based ST inhibitors are well-established, they are not membrane permeable. To tackle this problem, herein, we design and construct long-circulating, self-assembled core-shell nanoscale coordination polymer (NCP) nanoparticles carrying a transition state-based ST inhibitor, which make the inhibitor transmembrane and potently strip diverse sialoglycans from various cancer cells. In the experimental lung metastasis and metastasis prevention models, the nanoparticle device (NCP/STI) significantly inhibits metastases formation without systemic toxicity. This strategy enables ST inhibitors to be applied to cells and animals by providing them with a well-designed nanodelivery system. Our work opens a new avenue to the development of transition state-based ST inhibitors and demonstrates that NCP/STI holds great promise in achieving metastases inhibition for multiple cancers.

Details

Language :
English
ISSN :
1944-8252
Volume :
15
Issue :
6
Database :
MEDLINE
Journal :
ACS applied materials & interfaces
Publication Type :
Academic Journal
Accession number :
36728365
Full Text :
https://doi.org/10.1021/acsami.2c18601