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Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond.

Authors :
Yu W
Xie
Yamamoto T
Koyama H
Cheng J
Source :
Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2023 Apr; Vol. 24 (2), pp. 327-343. Date of Electronic Publication: 2023 Jan 30.
Publication Year :
2023

Abstract

Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder. The prevalence of hyperuricemia is increasing worldwide, with a growing trend in the younger populations. Although numerous studies have indicated that hyperuricemia may be an independent risk factor for insulin resistance, the causal relationship between the two is controversial. There are few reviews, however, focusing on the relationship between uric acid (UA) and insulin resistance from experimental studies. In this review, we summarized the experimental models related to soluble UA-induced insulin resistance in pancreas and peripheral tissues, including skeletal muscles, adipose tissue, liver, heart/cardiomyocytes, vascular endothelial cells and macrophages. In addition, we summarized the research advances about the key mechanism of UA-induced insulin resistance. Moreover, we attempt to identify novel targets for the treatment of hyperuricemia-related insulin resistance. Lastly, we hope that the present review will encourage further researches to solve the chicken-and-egg dilemma between UA and insulin resistance, and provide strategies for the pathogenesis and treatment of hyperuricemia related metabolic diseases.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Details

Language :
English
ISSN :
1573-2606
Volume :
24
Issue :
2
Database :
MEDLINE
Journal :
Reviews in endocrine & metabolic disorders
Publication Type :
Academic Journal
Accession number :
36715824
Full Text :
https://doi.org/10.1007/s11154-023-09787-4