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Development and validation of a nomogram for predicting survival in patients with acute pancreatitis.
- Source :
-
World journal of emergency medicine [World J Emerg Med] 2023; Vol. 14 (1), pp. 44-48. - Publication Year :
- 2023
-
Abstract
- Background: Acute pancreatitis (AP) is a complex and heterogeneous disease. We aimed to design and validate a prognostic nomogram for improving the prediction of short-term survival in patients with AP.<br />Methods: The clinical data of 632 patients with AP were obtained from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The nomogram for the prediction of 30-day, 60-day and 90-day survival was developed by incorporating the risk factors identified by multivariate Cox analyses.<br />Results: Multivariate Cox proportional hazard model analysis showed that age (hazard ratio [HR]=1.06, 95% confidence interval [95% CI] 1.03-1.08, P<0.001), white blood cell count (HR=1.03, 95% CI 1.00-1.06, P=0.046), systolic blood pressure (HR=0.99, 95% CI 0.97-1.00, P=0.015), serum lactate level (HR=1.10, 95% CI 1.01-1.20, P=0.023), and Simplified Acute Physiology Score II (HR=1.04, 95% CI 1.02-1.06, P<0.001) were independent predictors of 90-day mortality in patients with AP. A prognostic nomogram model for 30-day, 60-day, and 90-day survival based on these variables was built. Receiver operating characteristic (ROC) curve analysis demonstrated that the nomogram had good accuracy for predicting 30-day, 60-day, and 90-day survival (area under the ROC curve: 0.796, 0.812, and 0.854, respectively; bootstrap-corrected C-index value: 0.782, 0.799, and 0.846, respectively).<br />Conclusion: The nomogram-based prognostic model was able to accurately predict 30-day, 60-day, and 90-day survival outcomes and thus may be of value for risk stratification and clinical decision-making for critically ill patients with AP.<br />Competing Interests: Conflicts of interest: The authors report that there are no competing interests to declare.<br /> (Copyright: © World Journal of Emergency Medicine.)
Details
- Language :
- English
- ISSN :
- 1920-8642
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 36713344
- Full Text :
- https://doi.org/10.5847/wjem.j.1920-8642.2023.022