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Focused ultrasound-mediated brain genome editing.
- Source :
-
Research square [Res Sq] 2023 Jan 20. Date of Electronic Publication: 2023 Jan 20. - Publication Year :
- 2023
-
Abstract
- Gene editing in the mammalian brain has been challenging because of the restricted transport imposed by the blood-brain barrier (BBB). Current approaches rely on local injection to bypass the BBB. However, such administration is highly invasive and not amenable to treating certain delicate regions of the brain. We demonstrate a safe and effective gene editing technique by using focused ultrasound (FUS) to transiently open the BBB for the transport of intravenously delivered CRISPR/Cas9 machinery to the brain.
Details
- Language :
- English
- Database :
- MEDLINE
- Journal :
- Research square
- Accession number :
- 36712096
- Full Text :
- https://doi.org/10.21203/rs.3.rs-2365576/v1