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Chemical stability and physical compatibility of meropenem in admixtures for continuous and extended intravenous infusions.

Authors :
Giménez-Giner S
Llopis-Alemany A
Porta-Oltra B
Llopis-Salvia P
Climente-Martí M
Martínez-Gómez MA
Source :
Enfermedades infecciosas y microbiologia clinica (English ed.) [Enferm Infecc Microbiol Clin (Engl Ed)] 2023 Dec; Vol. 41 (10), pp. 612-616. Date of Electronic Publication: 2023 Jan 25.
Publication Year :
2023

Abstract

Introduction: Prolonged intravenous infusion of beta-lactams increase the clinical cure rate compared to conventional administration in critical or septic patients. This study aimed to determine chemical stability and physical compatibility of meropenem at conditions used in clinical practice to evaluate the stability of the preparation during its administration and the possibility of anticipated preparation.<br />Methods: Admixtures in study were: (i) meropenem 6g in 0.9% sodium chloride (NS) in infusor of 2mL/h 50mL or 10mL/h 240mL; (ii) meropenem 1 or 2g in NS in infusion bag of 250mL. Temperatures of study were: (i) infusor: 4.5°C, 32°C or 12h at 4.5°C followed by 32°C; (ii) Infusion bag: 4.5°C, 24.5°C or 6h at 4.5°C followed by 24.5°C. Time of study was 5-6 days in infusor and 1 day in infusion bag. Chemical stability was evaluated by high performance liquid chromatography and physical compatibility by measuring pH and visual inspection.<br />Results: Chemical stability and physical compatibility of meropenem in admixtures in infusors were reduced at high meropenem concentration and high temperature. Admixtures in infusion bag show chemical stability and physical compatibility for at least 1 day.<br />Conclusion: Administration of meropenem 6g in infusion of 24h in 240mL of 0.9% NaCl in infusor of 10mL/h could be possible if the admixture is infused at 4.5°C. Extended infusion of meropenem 1 or 2g in 0.9% NaCl in infusion bag (250mL) in 3-4h is also feasible. Anticipated preparation of the admixtures in infusion bag is possible with a stability of 24h.<br /> (Copyright © 2022 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.)

Details

Language :
English
ISSN :
2529-993X
Volume :
41
Issue :
10
Database :
MEDLINE
Journal :
Enfermedades infecciosas y microbiologia clinica (English ed.)
Publication Type :
Academic Journal
Accession number :
36707284
Full Text :
https://doi.org/10.1016/j.eimce.2022.07.010