Primary Cutaneous Anaplastic Large Cell Lymphoma With Gastric Metastasis.

Authors :: Khrais A
Abboud Y
Le A
Patel P
Vossough-Teehan S
Source :: Cureus [Cureus] 2022 Dec 25; Vol. 14 (12), pp. e32922. Date of Electronic Publication: 2022 Dec 25 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a subtype of non-Hodgkin lymphoma (NHL) that is localized to the skin. Disseminated disease is rare, and visceral organ involvement is even more so. We report a unique case of PCALCL with gastric metastasis. A 75-year-old man with a history of cutaneous left lower extremity PCALCL status post radiation therapy initially presented with abdominal pain and was found to have diffuse celiac axis and retroperitoneal lymphadenopathy. Endoscopy, initially done to biopsy an involved lymph node (LN), demonstrated a friable gastric nodular lesion with telangiectasias. Biopsy of the lesion and LN revealed anaplastic large cell lymphoma, identical in pathology to the known skin lesion. The patient was treated with systemic chemotherapy with a good response. PCALCL has been thought of as a localized malignancy with a good prognosis and low potential for extracutaneous spread. To our knowledge, this is the first instance of metastatic PCALCL involving the stomach.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright © 2022, Khrais et al.)