Impact of intentional weight loss in cardiometabolic disease: what we know about timing of benefits on differing outcomes?

Competing Interests: Conflict of interest: N.S. declares consulting fees or speaker honoraria from Abbott Laboratories, Afimmune, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hanmi Pharmaceuticals, Janssen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Roche Diagnostics, and Sanofi; and grant support paid to his university from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche Diagnostics, outside the submitted work. J.D. received consulting fees from GENinCode UK Ltd; received CME honoraria and/or consulting fees from Aegerion, Amgen, Bayer, Boehringer Ingelheim, Merck, Novartis, Novo Nordisk A/S, Pfizer, Sanofi, and Takeda; and holds the following unpaid positions: Chief Medical Advisor for Our Future Health, senior advisor for Cardiovascular Disease Prevention for Public Health England, and Chair of the NHS Healthcheck Expert Scientific and Clinical Advisory Panel (ESCAP) and Review of the National Health Check Programme for Public Health England. C.D. and N.S. are supported by the British Heart Foundation (Centre of Research Excellence, reference RE/18/6/34217).