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Metabolic Effects and Safety Aspects of Acute D-allulose and Erythritol Administration in Healthy Subjects.
- Source :
-
Nutrients [Nutrients] 2023 Jan 15; Vol. 15 (2). Date of Electronic Publication: 2023 Jan 15. - Publication Year :
- 2023
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Abstract
- The rapid increase in sugar consumption is associated with various negative metabolic and inflammatory effects; therefore, alternative sweeteners become of interest. The aim of this study was to investigate the metabolic effects and safety aspects of acute D-allulose and erythritol on glucose, insulin, ghrelin, blood lipids, uric acid, and high-sensitive C-reactive protein (hsCRP). In three study visits, 18 healthy subjects received an intragastric administration of 25 g D-allulose or 50 g erythritol, or 300 mL tap water (placebo) in a randomized, double-blind and crossover order. To measure the aforementioned parameters, blood samples were drawn at fixed time intervals. Glucose and insulin concentrations were lower after D-allulose compared to tap water ( p = 0.001, d <subscript>z</subscript> = 0.91 and p = 0.005, d <subscript>z</subscript> = 0.58, respectively); however, Bayesian models show no difference for insulin in response to D-allulose compared to tap water, and there was no effect after erythritol. An exploratory analysis showed that ghrelin concentrations were reduced after erythritol compared to tap water ( p = 0.026, d <subscript>z</subscript> = 0.59), with no effect after D-allulose; in addition, both sweeteners had no effect on blood lipids, uric acid and hsCRP. This combination of properties identifies both sweeteners as excellent candidates for effective and safe sugar alternatives.
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 36678329
- Full Text :
- https://doi.org/10.3390/nu15020458