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SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease.
- Source :
-
Molecular cell [Mol Cell] 2023 Jan 19; Vol. 83 (2), pp. 163-164. - Publication Year :
- 2023
-
Abstract
- To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al. <superscript>1</superscript> and Panditharatna et al. <superscript>2</superscript> performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF) chromatin remodeling complex.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4164
- Volume :
- 83
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 36669477
- Full Text :
- https://doi.org/10.1016/j.molcel.2022.12.028