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3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp.

3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp.

Authors :
Silva LC
Dos Santos Filho RF
de Oliveira AA
Martins FT
Cunha S
de Almeida Soares CM
Pereira M
Source :
Future microbiology [Future Microbiol] 2023 Jan; Vol. 18, pp. 93-105. Date of Electronic Publication: 2023 Jan 20.
Publication Year :
2023

Abstract

Aims: Considering the need to identify new compounds with antifungal action, the activity of five 3-phenacylideneoxindoles compounds was evaluated. Materials & methods: The compounds were synthesized, and their antifungal activity was elucidated through minimum inhibitory concentration tests and interaction assay with other antifungals. Potential targets of compounds were predicted in silico . Results: 3-phenacylideneoxindoles compounds inhibited fungal growth with minimum inhibitory concentration and minimum fungicidal concentration ranging from 3.05 to 12.26 μM. The compounds demonstrated high selectivity index and presented a synergistic effect with itraconazole. In silico prediction revealed the pentafunctional AROM polypeptide, enolase, superoxide dismutase, catalase and kinases as proteins targets of the compound 4a. Conclusion: The results demonstrate that 3-phenacylideneoxindoles is a potential new class of antifungal compounds for paracoccidioidomycosis treatment.

Details

Language :
English
ISSN :
1746-0921
Volume :
18
Database :
MEDLINE
Journal :
Future microbiology
Publication Type :
Academic Journal
Accession number :
36661071
Full Text :
https://doi.org/10.2217/fmb-2022-0133