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3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp.
3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp.
- Source :
-
Future microbiology [Future Microbiol] 2023 Jan; Vol. 18, pp. 93-105. Date of Electronic Publication: 2023 Jan 20. - Publication Year :
- 2023
-
Abstract
- Aims: Considering the need to identify new compounds with antifungal action, the activity of five 3-phenacylideneoxindoles compounds was evaluated. Materials & methods: The compounds were synthesized, and their antifungal activity was elucidated through minimum inhibitory concentration tests and interaction assay with other antifungals. Potential targets of compounds were predicted in silico . Results: 3-phenacylideneoxindoles compounds inhibited fungal growth with minimum inhibitory concentration and minimum fungicidal concentration ranging from 3.05 to 12.26 μM. The compounds demonstrated high selectivity index and presented a synergistic effect with itraconazole. In silico prediction revealed the pentafunctional AROM polypeptide, enolase, superoxide dismutase, catalase and kinases as proteins targets of the compound 4a. Conclusion: The results demonstrate that 3-phenacylideneoxindoles is a potential new class of antifungal compounds for paracoccidioidomycosis treatment.
Details
- Language :
- English
- ISSN :
- 1746-0921
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Future microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 36661071
- Full Text :
- https://doi.org/10.2217/fmb-2022-0133