End of the road: Astrocyte endfeet regulate OPC migration and myelination.

Authors :: Duncan GJ
Emery B
Source :: Neuron [Neuron] 2023 Jan 18; Vol. 111 (2), pp. 139-141.
Publication Year :: 2023
Abstract: Oligodendrocyte precursor cells (OPCs) use the vasculature as a scaffold for their migration. In this issue of Neuron, Su et al. determine that astrocytic ensheathment of the vasculature mediates OPC detachment from blood vessels via the secretion of semaphorins, regulating the timing of oligodendrocyte differentiation.<br />Competing Interests: Declaration of interests B.E. is a founder of and has received consulting fees from Autobahn Therapeutics.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)