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Review: bioavailability and efficacy of 'free' curcuminoids from curcumagalactomannoside (CGM) curcumin formulation.
- Source :
-
Nutrition research reviews [Nutr Res Rev] 2024 Jun; Vol. 37 (1), pp. 14-31. Date of Electronic Publication: 2023 Jan 19. - Publication Year :
- 2024
-
Abstract
- The golden spice turmeric with its main bioactive component curcumin is one of the most popular and extensively studied nutraceuticals. Despite numerous pre-clinical studies reporting positive pharmacodynamics of turmeric extracts and curcumin, the main issues in translating the pharmacological effects to clinical efficacy have been to overcome its poor pharmacokinetics and to deliver significant amounts of the biologically relevant forms of the actives to various tissues. This review is aimed at providing a first critical evaluation of the current published literature with the novel curcumagalactomannoside (CGM) formulation of curcumin using fenugreek galactomannan dietary fibre, specifically designed to address curcumin poor pharmacokinetics. We describe CGM and its technology as a food-grade formulation to deliver 'free' unconjugated curcuminoids with enhanced bioavailability and improved pharmacokinetic properties. The therapeutic relevance of improving bioavailability of 'free' curcuminoids and some of the technical challenges in the measurement of the 'free' form of curcuminoids in plasma and tissues are also discussed. A total of twenty-six manuscripts are reviewed here, including fourteen pre-clinical and twelve clinical studies that have investigated CGM pharmacokinetics, safety and efficacy in various animal models and human conditions. Overall current scientific evidence suggests CGM formulation has improved bioavailability and tissue distribution of the biologically relevant unconjugated forms of turmeric actives called 'free' curcuminoids that may be responsible for the superior clinical outcomes reported with CGM treatments in comparison with unformulated standard curcumin across multiple studies.
- Subjects :
- Humans
Animals
Plant Extracts pharmacokinetics
Plant Extracts pharmacology
Mannans pharmacology
Mannans pharmacokinetics
Mannans chemistry
Dietary Fiber pharmacology
Dietary Supplements
Curcumin pharmacokinetics
Curcumin administration & dosage
Biological Availability
Curcuma chemistry
Trigonella chemistry
Galactose analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2700
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition research reviews
- Publication Type :
- Academic Journal
- Accession number :
- 36655498
- Full Text :
- https://doi.org/10.1017/S0954422423000033