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The potential benefits and mechanisms of protein nutritional intervention on bone health improvement.
- Source :
-
Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2024 Jun; Vol. 64 (18), pp. 6380-6394. Date of Electronic Publication: 2023 Jan 19. - Publication Year :
- 2024
-
Abstract
- Osteoporosis commonly occurs in the older people and severe patients, with the main reason of the imbalance of bone metabolism (the rate of bone resorption exceeding the rate of bone formation), resulting in a decrease in bone mineral density and destruction of bone microstructure and further leading to the increased risk of fragility fracture. Recent studies indicate that protein nutritional support is beneficial for attenuating osteoporosis and improving bone health. This review summarized the classical mechanisms of protein intervention for alleviating osteoporosis on both suppressing bone resorption and regulating bone formation related pathways (promoting osteoblasts generation and proliferation, enhancing calcium absorption, and increasing collagen and mineral deposition), as well as the potential novel mechanisms via activating autophagy of osteoblasts, altering bone related miRNA profiles, regulating muscle-bone axis, and modulating gut microbiota abundance. Protein nutritional intervention is expected to provide novel approaches for the prevention and adjuvant therapy of osteoporosis.
- Subjects :
- Humans
Gastrointestinal Microbiome physiology
MicroRNAs metabolism
Bone Resorption diet therapy
Bone Resorption prevention & control
Autophagy
Osteogenesis
Animals
Osteoporosis prevention & control
Osteoporosis diet therapy
Dietary Proteins administration & dosage
Bone and Bones metabolism
Bone Density
Osteoblasts physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1549-7852
- Volume :
- 64
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Critical reviews in food science and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 36655469
- Full Text :
- https://doi.org/10.1080/10408398.2023.2168250