Back to Search
Start Over
Comparative Evaluation of Prevalence, Risk Factors, and Pathologic Features of Kidney Disease in Highly Active Antiretroviral Therapy-Naive and Highly Active Antiretroviral Therapy-Experienced Patients at a Tertiary Health Facility in Maiduguri, Northeastern Nigeria.
- Source :
-
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia [Saudi J Kidney Dis Transpl] 2022 Jan-Feb; Vol. 33 (1), pp. 72-79. - Publication Year :
- 2022
-
Abstract
- Infection of the kidneys by human immunodeficiency virus (HIV) is known to cause kidney disease. HIV-associated nephropathy occurs with variable prevalence rates in various communities and is found to be higher among sub-Saharan Africans. The disease has not been studied in Northeastern Nigeria. This study was aimed at comparing the prevalence, clinical and histo-pathologic features of kidney disease among highly active antiretroviral therapy (HAART)-experienced and HAART-naive patients in northeastern Nigeria. Four hundred HIV-infected (200 HAART-experienced and 200 HAART-naïve) patients were recruited consecutively from the ART clinic. Their socio-demographic and laboratory data including CD4+ cell counts and viral loads were obtained and documented. Out of the 200 study participants in the HAART-experienced arm, 21 (10.5%) had kidney disease whereas 61 (30.5%) participants in the HAART-naïve group had kidney disease. Their mean ages were 41.43 ± 11.04 years and 37.42 ± 9.96 years in the HAART-experienced and HAART-naïve groups, respectively. The mean serum creatinine (SCr), CD4 <superscript>+</superscript> cell counts, and viral load were 185.67 ± 221.80 μmol/L, 493.26 ± 241.97/mm <superscript>3</superscript> , and 8,856.79 ± 19,747.11/mL in the HAART-experienced group, respectively. In the HAART-naïve group, the mean SCr, CD4 <superscript>+</superscript> cell count, and viral load were 141.88 ± 130.56 μmol/L, 270.00 ± 154.65 cells/mm <superscript>3</superscript> , and 139,217.70 ± 12,598.50/mL. Focal segmental glomerulosclerosis (FSGS) was the most common histologic diagnosis in 64.7% of kidney biopsies. Risk factors for chronic kidney disease among the study population included age, low weight and body mass index, high human immunodeficiency virus (HIV)-1 viral load, low CD4+ cell counts, low hemoglobin (Hb), and proteinuria. The prevalence of kidney disease is higher among HAART-naïve HIV-infected patients than in patients who are HAART-experienced patients. Factors associated with development of kidney disease included advanced age, low CD4 <superscript>+</superscript> cell counts, high viral load, proteinuria, and HAART-naivety. FSGS is the most common histologic diagnosis in our study population.<br />Competing Interests: None
- Subjects :
- Humans
Adult
Middle Aged
Antiretroviral Therapy, Highly Active adverse effects
Prevalence
Nigeria epidemiology
Risk Factors
Health Facilities
CD4 Lymphocyte Count
Viral Load
HIV Infections drug therapy
HIV Infections epidemiology
HIV Infections complications
Glomerulosclerosis, Focal Segmental drug therapy
Kidney Diseases diagnosis
Kidney Diseases epidemiology
Kidney Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1319-2442
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
- Publication Type :
- Academic Journal
- Accession number :
- 36647981
- Full Text :
- https://doi.org/10.4103/1319-2442.367828