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Reverse Engineering Caged Compounds: Design Principles for their Application in Biology.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Feb 20; Vol. 62 (9), pp. e202206083. Date of Electronic Publication: 2023 Jan 16. - Publication Year :
- 2023
-
Abstract
- Light passes through biological tissue, and so it is used for imaging biological processes in situ. Such observation is part of the very essence of science, but mechanistic understanding requires intervention. For more than 50 years a "second function" for light has emerged; namely, that of photochemical control. Caged compounds are biologically inert signaling molecules that are activated by light. These optical probes enable external instruction of biological processes by stimulation of an individual element in complex signaling cascades in its native environment. Cause and effect are linked directly in spatial, temporal, and frequency domains in a quantitative manner by their use. I provide a guide to the basic properties required to make effective caged compounds for the biological sciences.<br /> (© 2023 Wiley-VCH GmbH.)
- Subjects :
- Photochemistry methods
Signal Transduction
Biology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 62
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 36646644
- Full Text :
- https://doi.org/10.1002/anie.202206083