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Solution of the protein structure prediction problem at last: crucial innovations and next frontiers.

Authors :
Agard DA
Bowman GR
DeGrado W
Dokholyan NV
Zhou HX
Source :
Faculty reviews [Fac Rev] 2022 Dec 14; Vol. 11, pp. 38. Date of Electronic Publication: 2022 Dec 14 (Print Publication: 2022).
Publication Year :
2022

Abstract

The protein structure prediction problem is solved, at last, thanks in large part to the use of artificial intelligence. The structures predicted by AlphaFold and RoseTTAFold are becoming the requisite starting point for many protein scientists. New frontiers, such as the conformational sampling of intrinsically disordered proteins, are emerging.<br />Competing Interests: The authors declare that they have no competing interests.<br /> (Copyright: © 2022 Faculty Opinions Ltd.)

Details

Language :
English
ISSN :
2732-432X
Volume :
11
Database :
MEDLINE
Journal :
Faculty reviews
Publication Type :
Academic Journal
Accession number :
36644294
Full Text :
https://doi.org/10.12703/r-01-0000020