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Prevalence of hemorrhagic ovarian cysts in patients with rare inherited bleeding disorders.
- Source :
-
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2023 Jun; Vol. 62 (3), pp. 103636. Date of Electronic Publication: 2022 Dec 17. - Publication Year :
- 2023
-
Abstract
- Background: In comparison with the general population, women with bleeding disorders are more prone to develop obstetrical and gynecological problems. However, no comprehensive evaluation has investigated the prevalence of hemorrhagic ovarian cysts (HOCs) in rare bleeding disorders (RBDs). In this study, we sought to determine the prevalence of HOCs in a large cohort of Iranian patients with RBDs.<br />Methods: A total of 210 symptomatic patients suspected of HOCs with RBD were included. The median age of the study population was 24 years. Patients were diagnosed with fibrinogen disorders (n = 7, 3%), factor (F) II (n = 4, 2%), FV (n = 28, 13%), FVII (n = 4, 2%), FX (n = 6, 3%), FXIII (n = 122, 58%), combined FV and FVIII (n = 8, 4%), Glanzmann's thrombasthenia (n = 10, 5%), and von Willebrand disease (VWD) type 3 (n = 21, 10%).<br />Results: Following further clinical and ultrasound examinations of these 210 patients, 68 (32.4%) were confirmed with a diagnosis of HOCs. Of which, FXIII deficiency with 46 cases (67.6%), followed by VWD type 3 (6 cases, 8.8%) showed the highest number. Other coagulation defects associated with HOCs were including fibrinogen deficiency (n = 2, 3%), FII (n = 2, 3%), FV (n = 4, 6%), FVII (n = 2, 3%), FX (n = 1, 1.5%), combined FV and FVIII (n = 2, 3%), and Glanzmann's thrombasthenia (n = 3, 4.5%).<br />Conclusion: This study found a high prevalence of HOCs in patients with RBDs, indicating the importance of early diagnosis and optimal management of obstetric and gynecological complications in these patients.<br />Competing Interests: Conflict-of-interest disclosure The authors declare no conflicts of interest relevant to this manuscript.<br /> (Copyright © 2023. Published by Elsevier Ltd.)
- Subjects :
- Humans
Female
Young Adult
Adult
Prevalence
Iran epidemiology
Hemorrhage epidemiology
Hemorrhage complications
Rare Diseases diagnosis
Thrombasthenia
Blood Coagulation Disorders, Inherited diagnosis
Blood Coagulation Disorders complications
Hemorrhagic Disorders epidemiology
Ovarian Cysts epidemiology
Ovarian Cysts complications
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0502
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Publication Type :
- Academic Journal
- Accession number :
- 36635175
- Full Text :
- https://doi.org/10.1016/j.transci.2022.103636