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Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.
- Source :
-
Science (New York, N.Y.) [Science] 2023 Jan 13; Vol. 379 (6628), pp. eabl3837. Date of Electronic Publication: 2023 Jan 13. - Publication Year :
- 2023
-
Abstract
- Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
- Subjects :
- Animals
Interferon-gamma metabolism
Signal Transduction
Ixodes genetics
Ixodes immunology
Janus Kinases genetics
Janus Kinases metabolism
STAT Transcription Factors genetics
STAT Transcription Factors metabolism
Host-Parasite Interactions immunology
Receptors, Cytokine metabolism
Arachnid Vectors immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 379
- Issue :
- 6628
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 36634189
- Full Text :
- https://doi.org/10.1126/science.abl3837