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Understanding and modeling nerve-cancer interactions.
- Source :
-
Disease models & mechanisms [Dis Model Mech] 2023 Jan 01; Vol. 16 (1). Date of Electronic Publication: 2023 Jan 09. - Publication Year :
- 2023
-
Abstract
- The peripheral nervous system plays an important role in cancer progression. Studies in multiple cancer types have shown that higher intratumoral nerve density is associated with poor outcomes. Peripheral nerves have been shown to directly regulate tumor cell properties, such as growth and metastasis, as well as affect the local environment by modulating angiogenesis and the immune system. In this Review, we discuss the identity of nerves in organs in the periphery where solid tumors grow, the known mechanisms by which nerve density increases in tumors, and the effects these nerves have on cancer progression. We also discuss the strengths and weaknesses of current in vitro and in vivo models used to study nerve-cancer interactions. Increased understanding of the mechanisms by which nerves impact tumor progression and the development of new approaches to study nerve-cancer interactions will facilitate the discovery of novel treatment strategies to treat cancer by targeting nerves.<br />Competing Interests: Competing interests The authors declare no competing or financial interests.<br /> (© 2023. Published by The Company of Biologists Ltd.)
- Subjects :
- Humans
Neoplasms pathology
Nerve Tissue
Subjects
Details
- Language :
- English
- ISSN :
- 1754-8411
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Disease models & mechanisms
- Publication Type :
- Academic Journal
- Accession number :
- 36621886
- Full Text :
- https://doi.org/10.1242/dmm.049729