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Telomere Length and Telomerase Activity in Subcutaneous and Visceral Adipose Tissues from Obese and Non-Obese Patients with and without Colorectal Cancer.

Authors :
García-Martínez S
González-Gamo D
Tesolato SE
Barabash A
de la Serna SC
Domínguez-Serrano I
Dziakova J
Rivera D
Torres AJ
Iniesta P
Source :
Cancers [Cancers (Basel)] 2022 Dec 31; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 31.
Publication Year :
2022

Abstract

To investigate the molecular mechanisms that link obesity and colorectal cancer (CRC), we analyzed parameters related to telomere function in subcutaneous and visceral adipose tissues (SAT and VAT), including subjects with and without CRC, who were classified according to their body mass index (BMI). Adipose tissues were obtained from 147 patients who had undergone surgery. A total of 66 cases corresponded to CRC patients, and 81 subjects were not affected by cancer. Relative telomere length was established by qPCR, and telomerase activity was determined by a method based on the telomeric repeat amplification protocol. Our results indicated longer telomeres in patients affected by CRC, both in SAT and VAT, when compared to the group of subjects without CRC. Tumor local invasion was associated with telomere length (TL) in SAT. Considering the BMI values, significant differences were found in the TL of both adipose tissues between subjects affected by CRC and those without cancer. Overweight subjects showed the greatest differences, with longer telomeres in the group of CRC patients, and a higher number of cases with telomerase reactivation in the VAT of subjects without cancer. In conclusion, parameters related to telomere function in adipose tissue could be considered as potential biomarkers in the evaluation of CRC and obesity.

Details

Language :
English
ISSN :
2072-6694
Volume :
15
Issue :
1
Database :
MEDLINE
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
36612269
Full Text :
https://doi.org/10.3390/cancers15010273