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Functional geometry of the cortex encodes dimensions of consciousness.
- Source :
-
Nature communications [Nat Commun] 2023 Jan 05; Vol. 14 (1), pp. 72. Date of Electronic Publication: 2023 Jan 05. - Publication Year :
- 2023
-
Abstract
- Consciousness is a multidimensional phenomenon, but key dimensions such as awareness and wakefulness have been described conceptually rather than neurobiologically. We hypothesize that dimensions of consciousness are encoded in multiple neurofunctional dimensions of the brain. We analyze cortical gradients, which are continua of the brain's overarching functional geometry, to characterize these neurofunctional dimensions. We demonstrate that disruptions of human consciousness - due to pharmacological, neuropathological, or psychiatric causes - are associated with a degradation of one or more of the major cortical gradients depending on the state. Network-specific reconfigurations within the multidimensional cortical gradient space are associated with behavioral unresponsiveness of various etiologies, and these spatial reconfigurations correlate with a temporal disruption of structured transitions of dynamic brain states. In this work, we therefore provide a unifying neurofunctional framework for multiple dimensions of human consciousness in both health and disease.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Wakefulness
Brain Mapping methods
Consciousness
Brain
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 36604428
- Full Text :
- https://doi.org/10.1038/s41467-022-35764-7