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Assembly of biomimetic microreactors using caged-coacervate droplets.
- Source :
-
Nanoscale [Nanoscale] 2023 Feb 09; Vol. 15 (6), pp. 2561-2566. Date of Electronic Publication: 2023 Feb 09. - Publication Year :
- 2023
-
Abstract
- Complex coacervates are liquid-like droplets that can be used to create adaptive cell-like compartments. These compartments offer a versatile platform for the construction of bioreactors inspired by living cells. However, the lack of a membrane significantly reduces the colloidal stability of coacervates in terms of fusion and surface wetting, which limits their suitability as compartments. Here, we describe the formation of caged-coacervates surrounded by a semipermeable shell of silica nanocapsules. We demonstrate that the silica nanocapsules create a protective shell that also regulates the molecular transport of water-soluble compounds as a function of nanocapasule size. The adjustable semipermeability and intrinsic affinity of enzymes for the interior of the caged-coacervates allowed us to assemble biomimetic microreactors with enhanced colloidal stability.
- Subjects :
- Water
Wettability
Biomimetics
Nanocapsules
Subjects
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 36601867
- Full Text :
- https://doi.org/10.1039/d2nr05101j