The effect of TiO 2 nanoparticles on bacterial growth: the effect of particle size and their structure - a systematic review.

One of the widely used microbiological methods to determine the toxicity of chemicals, catalysts, and other types of materials is the minimum inhibitory concentration (MIC) test. The present study aims to investigate the influence of composition of composite materials based on TiO ₂ and their particle size as well as bacterial type and shape based on the MIC values reported in the literature. The results show that among the 36 articles selected, most of the studies used Escherichia coli ( E. coli ) (26) and Staphylococcus aureus ( S. aureus ) (19) bacteria to determine MIC values. This study revealed that the MIC in values below 70 µg ml ^-1 for S. aureus was lower than that for E. coli bacteria (below 200 µg ml ^-1 ). Importantly, MIC value decreased from 60.6 to 7.66 µg ml ^-1 with decrease in the size of nanoparticles. It follows from the increased surface area for smaller-sized particles, thus increased interaction with bacteria during MIC test.