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Effects of anti-ulcer drugs on delirium in trauma patients.

Authors :: Sogawa R
Matsuoka A
Murakawa-Hirachi T
Kikkawa N
Kamo M
Tobita S
Shinada K
Mizoguchi Y
Monji A
Sakamoto Y
Shimanoe C
Source :: General hospital psychiatry [Gen Hosp Psychiatry] 2023 Jan-Feb; Vol. 80, pp. 43-47. Date of Electronic Publication: 2022 Dec 29.
Publication Year :: 2023
Abstract: Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.<br />Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.<br />Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04-3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71-2.23).<br />Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)