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Incident dementia and long-term exposure to constituents of fine particle air pollution: A national cohort study in the United States.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2211282119. Date of Electronic Publication: 2022 Dec 27. - Publication Year :
- 2023
-
Abstract
- Growing evidence suggests that fine particulate matter (PM <subscript>2.5</subscript> ) likely increases the risks of dementia, yet little is known about the relative contributions of different constituents. Here, we conducted a nationwide population-based cohort study (2000 to 2017) by integrating the Medicare Chronic Conditions Warehouse database and two independently sourced datasets of high-resolution PM <subscript>2.5</subscript> major chemical composition, including black carbon (BC), organic matter (OM), nitrate (NO <subscript>3</subscript> <superscript>-</superscript> ), sulfate (SO <subscript>4</subscript> <superscript>2-</superscript> ), ammonium (NH <subscript>4</subscript> <superscript>+</superscript> ), and soil dust (DUST). To investigate the impact of long-term exposure to PM <subscript>2.5</subscript> constituents on incident all-cause dementia and Alzheimer's disease (AD), hazard ratios for dementia and AD were estimated using Cox proportional hazards models, and penalized splines were used to evaluate potential nonlinear concentration-response (C-R) relationships. Results using two exposure datasets consistently indicated higher rates of incident dementia and AD for an increased exposure to PM <subscript>2.5</subscript> and its major constituents. An interquartile range increase in PM <subscript>2.5</subscript> mass was associated with a 6 to 7% increase in dementia incidence and a 9% increase in AD incidence. For different PM <subscript>2.5</subscript> constituents, associations remained significant for BC, OM, SO <subscript>4</subscript> <superscript>2-</superscript> , and NH <subscript>4</subscript> <superscript>+</superscript> for both end points (even after adjustments of other constituents), among which BC and SO <subscript>4</subscript> <superscript>2-</superscript> showed the strongest associations. All constituents had largely linear C-R relationships in the low exposure range, but most tailed off at higher exposure concentrations. Our findings suggest that long-term exposure to PM <subscript>2.5</subscript> is significantly associated with higher rates of incident dementia and AD and that SO <subscript>4</subscript> <superscript>2-</superscript> , BC, and OM related to traffic and fossil fuel combustion might drive the observed associations.
- Subjects :
- Humans
Aged
United States epidemiology
Cohort Studies
Medicare
Particulate Matter adverse effects
Particulate Matter analysis
Dust
Environmental Exposure adverse effects
China
Air Pollutants adverse effects
Air Pollutants analysis
Air Pollution adverse effects
Air Pollution analysis
Dementia chemically induced
Dementia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 120
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 36574646
- Full Text :
- https://doi.org/10.1073/pnas.2211282119