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Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2023 Jan; Vol. 241, pp. 154277. Date of Electronic Publication: 2022 Dec 19. - Publication Year :
- 2023
-
Abstract
- Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer and the third leading cause of cancer-related deaths. Therefore, there is an urgent need for a novel molecular target for the treatment of PDAC. Kinesin family member C1 (KIFC1) belongs to the kinesin superfamily proteins and has been reported to be involved in the pathogenesis of a wide variety of carcinomas. However, the role of KIFC1 in PDAC remains unknown. This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those of negative control siRNA-transfected cells. Therefore, our findings suggest that KIFC1 is an independent prognostic factor in PDAC and may represent a new promising therapeutic target in PDAC.<br />Competing Interests: Conflicts of interest The authors declare that there are no conflicts of interest.<br /> (Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.)
- Subjects :
- Humans
Biomarkers, Tumor metabolism
Cell Line, Tumor
Cell Proliferation
Family
Gene Expression Regulation, Neoplastic
Kinesins genetics
Kinesins metabolism
Neoplastic Processes
Prognosis
RNA, Small Interfering
Neoplastic Stem Cells
Pancreatic Neoplasms
Carcinoma, Pancreatic Ductal genetics
Pancreatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 241
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 36565617
- Full Text :
- https://doi.org/10.1016/j.prp.2022.154277