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Characteristics, treatment and outcomes of HER2 positive male breast cancer.
- Source :
-
American journal of surgery [Am J Surg] 2023 Mar; Vol. 225 (3), pp. 489-493. Date of Electronic Publication: 2022 Dec 09. - Publication Year :
- 2023
-
Abstract
- Background: Research describing male breast cancer with HER2 overexpression is limited. This study evaluated the characteristics, treatment, and outcomes of HER2 positive breast cancer in men.<br />Methods: Information for January 2010 through December 2017 was obtained from the SEER Research Plus database.<br />Results: Four hundred sixty-two men were HER2 positive (13%) of 3594 cases of breast cancer. Compared to HER2 negative patients, these patients were younger at diagnosis (63 vs. 67 years, p < 0.001), had more poorly differentiated cancer (Grade III 53% vs. 33%, p < 0.001), and larger tumor size (28.8 vs. 24.6 mm, p < 0.001). HER2 positive males also had distant site and/or contralateral lymph node involvement more often (13% vs. 7%, p < 0.001), had higher rate of cancer-related mortality (15% vs. 10%, p = 0.002), and shorter overall survival (34 vs. 38 months, p = 0.004).<br />Conclusion: Men diagnosed with HER2 positive breast cancer had more advanced disease at diagnosis and worse outcomes than HER2 negative men despite increased utilization of systemic therapy.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1883
- Volume :
- 225
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 36564243
- Full Text :
- https://doi.org/10.1016/j.amjsurg.2022.12.009