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Alzheimer's disease-like cortical atrophy mediates the effect of air pollution on global cognitive function.
- Source :
-
Environment international [Environ Int] 2023 Jan; Vol. 171, pp. 107703. Date of Electronic Publication: 2022 Dec 17. - Publication Year :
- 2023
-
Abstract
- Little is known about the effect of air pollution on Alzheimer's disease (AD)-specific brain structural pathologies. There is also a lack of evidence on whether this effect leads to poorer cognitive function. We investigated whether, and the extent to which, AD-like cortical atrophy mediated the association between air pollution exposures and cognitive function in dementia-free adults. We used cross-sectional data from 640 participants who underwent brain magnetic resonance imaging and the Montreal Cognitive Assessment (MoCA). Mean cortical thickness (as the measure of global cortical atrophy) and machine learning-based AD-like cortical atrophy score were estimated from brain images. Concentrations of particulate matter with diameters ≤ 10 μm (PM <subscript>10</subscript> ) and ≤ 2.5 μm (PM <subscript>2.5</subscript> ) and nitrogen dioxide (NO <subscript>2</subscript> ) were estimated based on each participant's residential address. Following the product method, a mediation effect was tested by conducting a series of three regression analyses (exposure to outcome; exposure to mediator; and exposure and mediator to outcome). A 10 μg/m <superscript>3</superscript> increase in PM <subscript>10</subscript> (β = -1.13; 95 % CI, -1.73 to -0.53) and a 10 ppb increase in NO <subscript>2</subscript> (β = -1.09; 95 % CI, -1.40 to -0.78) were significantly associated with a lower MoCA score. PM <subscript>10</subscript> (β = 0.27; 95 % CI, 0.06 to 0.48) and NO <subscript>2</subscript> (β = 0.35; 95 % CI, 0.25 to 0.45) were significantly associated with an increased AD-like cortical atrophy score. Effects of PM <subscript>10</subscript> and NO <subscript>2</subscript> on MoCA scores were significantly mediated by mean cortical thickness (proportions mediated: 25 %-28 %) and AD-like cortical atrophy scores (13 %-16 %). The findings suggest that air pollution exposures may induce AD-like cortical atrophy, and that this effect may lead to poorer cognitive function in dementia-free adults.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Adult
Humans
Nitrogen Dioxide adverse effects
Nitrogen Dioxide analysis
Cross-Sectional Studies
Particulate Matter toxicity
Particulate Matter analysis
Cognition
Environmental Exposure adverse effects
Environmental Exposure analysis
Atrophy
Air Pollutants toxicity
Air Pollutants analysis
Alzheimer Disease etiology
Air Pollution adverse effects
Air Pollution analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6750
- Volume :
- 171
- Database :
- MEDLINE
- Journal :
- Environment international
- Publication Type :
- Academic Journal
- Accession number :
- 36563596
- Full Text :
- https://doi.org/10.1016/j.envint.2022.107703