Bidirectional hyperelastic characterization of brain white matter tissue.

Biomechanical study of brain injuries originated from mechanical damages to white matter tissue requires detailed information on mechanical characteristics of its main components, the axonal fibers and extracellular matrix, which is very limited due to practical difficulties of direct measurement. In this paper, a new theoretical framework was established based on microstructural modeling of brain white matter tissue as a soft composite for bidirectional hyperelastic characterization of its main components. First the tissue was modeled as an Ogden hyperelastic material, and its principal Cauchy stresses were formulated in the axonal and transverse directions under uniaxial and equibiaxial tension using the theory of homogenization. Upon fitting these formulae to the corresponding experimental test data, direction-dependent hyperelastic constants of the tissue were obtained. These directional properties then were used to estimate the strain energy stored in the homogenized model under each loading scenario. A new microstructural composite model of the tissue was also established using principles of composites micromechanics, in which the axonal fibers and surrounding matrix are modeled as different Ogden hyperelastic materials with unknown constants. Upon balancing the strain energies stored in the homogenized and composite models under different loading scenarios, fully coupled nonlinear equations as functions of unknown hyperelastic constants were derived, and their optimum solutions were found in a multi-parametric multi-objective optimization procedure using the response surface methodology. Finally, these solutions were implemented, in a bottom-up approach, into a micromechanical finite element model to reproduce the tissue responses under the same loadings and predict the tissue responses under unseen non-equibiaxial loadings. Results demonstrated a very good agreement between the model predictions and experimental results in both directions under different loadings. Moreover, the axonal fibers with hyperelastic characteristics stiffer than the extracellular matrix were shown to play the dominant role in directional reinforcement of the tissue.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)