ETS Fight Club on Microsatellite Enhancers.

Authors :: Mercher T
Source :: Blood cancer discovery [Blood Cancer Discov] 2023 Jan 06; Vol. 4 (1), pp. 2-4.
Publication Year :: 2023
Abstract: In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovichet al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1-translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription. See related article by Kodgule, Goldman, Monovich et al., p. 34 (5).<br /> (©2022 American Association for Cancer Research.)