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Levetiracetam induces severe psychiatric symptoms in people with epilepsy.
- Source :
-
Seizure [Seizure] 2024 Mar; Vol. 116, pp. 147-150. Date of Electronic Publication: 2022 Dec 14. - Publication Year :
- 2024
-
Abstract
- Background: Drug-induced psychiatric symptoms are an important cause of treatment failure. Worldwide, levetiracetam has been widely used to treat epilepsy; however, associated psychobehavioral abnormalities have been observed . This study aimed to characterize levetiracetam-induced severe psychiatric symptoms and to propose preventive and therapeutic measures.<br />Methods: In this retrospective cluster sampling study, psychiatric symptoms of patients who had taken levetiracetam for at least 1 month were analyzed.<br />Results: 111(7.8%) of the 1,412 included patients exhibited severe psychiatric symptoms. Hallucinations, delusions, aggressive behavior, and agitation were the most common manifestations . Some patients also showed suicidal and self-harm behaviors. These symptoms were mainly controlled by reducing the dose of levetiracetam, stopping the drug, or adding antipsychotic drugs to the treatment regimen.<br />Conclusion: The severe psychiatric symptoms caused by levetiracetam require special attention.<br /> (Copyright © 2022. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1532-2688
- Volume :
- 116
- Database :
- MEDLINE
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 36535885
- Full Text :
- https://doi.org/10.1016/j.seizure.2022.12.002