Back to Search
Start Over
The effect of the ergoline derivative, CU 32-085, on prolactin secretion in hyperprolactinemic women.
- Source :
-
Fertility and sterility [Fertil Steril] 1987 Oct; Vol. 48 (4), pp. 555-9. - Publication Year :
- 1987
-
Abstract
- Twelve hyperprolactinemic women were administered the alpha aminoergoline derivative, CU 32-085 (Sandoz, Inc., East Hanover, NJ), in order to determine its effect on prolactin (PRL) secretion. The mean pretreatment serum PRL level was 145.0 +/- 11.5 ng/ml. Significant declines of serum PRL occurred with total daily doses of CU 32-085 of 0.1 to 0.5 mg (P less than 0.001). The magnitude of response to therapy was dose-related. In six patients, PRL levels were reduced to less than 25 ng/ml; this effect lasted at least 24 hours after intake of a single dose. In the other six patients, the response was less dramatic. No subjects developed adverse cardiovascular side effects. The results of this study demonstrate that CU 32-085 exhibits a clinically significant dopaminomimetic action on PRL secretion in hyperprolactinemic women.
- Subjects :
- Adenoma complications
Adult
Ergolines administration & dosage
Female
Humans
Hyperprolactinemia etiology
Hyperprolactinemia physiopathology
Kinetics
Menstruation Disturbances drug therapy
Pituitary Neoplasms complications
Ergolines therapeutic use
Hyperprolactinemia drug therapy
Prolactin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0015-0282
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 3653414