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Pathophysiological Changes in the Hemostatic System and Antithrombotic Management in Kidney Transplant Recipients.

Authors :
van den Berg TAJ
Nieuwenhuijs-Moeke GJ
Lisman T
Moers C
Bakker SJL
Pol RA
Source :
Transplantation [Transplantation] 2023 Jun 01; Vol. 107 (6), pp. 1248-1257. Date of Electronic Publication: 2023 May 23.
Publication Year :
2023

Abstract

Nowadays, the main cause for early graft loss is renal graft thrombosis because kidney transplant outcomes have improved drastically owing to advances in immunological techniques and immunosuppression. However, data regarding the efficacy of antithrombotic therapy in the prevention of renal graft thrombosis are scarce. Adequate antithrombotic management requires a good understanding of the pathophysiological changes in the hemostatic system in patients with end-stage kidney disease (ESKD). Specifically, ESKD and dialysis disrupt the fine balance between pro- and anticoagulation in the body, and further changes in the hemostatic system occur during kidney transplantation. Consequently, kidney transplant recipients paradoxically are at risk for both thrombosis and bleeding. This overview focuses on the pathophysiological changes in hemostasis in ESKD and kidney transplantation and provides a comprehensive summary of the current evidence for antithrombotic management in (adult) kidney transplant recipients.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.)

Details

Language :
English
ISSN :
1534-6080
Volume :
107
Issue :
6
Database :
MEDLINE
Journal :
Transplantation
Publication Type :
Academic Journal
Accession number :
36529881
Full Text :
https://doi.org/10.1097/TP.0000000000004452