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Phototheranostics for NIR fluorescence image guided PDT/PTT with extended conjugation and enhanced TICT.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Feb; Vol. 158, pp. 114071. Date of Electronic Publication: 2022 Dec 14. - Publication Year :
- 2023
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Abstract
- Introducing donor and acceptor into conjugated system can facilitate the intersystem crossing (ISC) rate to increase the generation of ROS. Twisted intramolecular charge transfer (TICT) state could favor enhance the nonradiative transition and photothermal conversion efficiency (PCE). Herein, diketopyrrolopyrrole (DPP) core functionalized benzene (PDDP), thiophene (TDPP), triphenylamine-conjugated benzene (TPA-PDDP) and thiophene (TPA-TDPP) derivatives were designed and synthesized. Electrochemistry experiments revealed the heavy atom effect and the introduction of triphenylamine reduced the energy level of TPA-TDPP and improved the ability to generate <superscript>1</superscript> O <subscript>2</subscript> ( <superscript>1</superscript> O <subscript>2</subscript> QY = 50%). In addition, in the aggregated state, introduction of thiophene, triphenylamine, and long alkyl chains promoted the twisting effect, preventing the intermolecular π-π interaction and enhancing the PCE of TPA-TDPP (38.7%). In vivo fluorescence imaging showed that TPA-TDPP NPs can target the tumor site with the enhanced permeability and retention (EPR) effect and presented excellent synergistic photodynamic/photothermal therapy.<br />Competing Interests: Conflicts of interest statement There are no conflicts to declare.<br /> (Copyright © 2022. Published by Elsevier Masson SAS.)
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 158
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 36525820
- Full Text :
- https://doi.org/10.1016/j.biopha.2022.114071