Molecular docking analysis of flavonoids with aldose reductase.

Authors :: Kannayiram K
Umapathy VR
Chamundeswari Y
Fathima JH
Govindan R
Palanisamy CP
Veeraraghavan VP
Jayaraman S
Rajagopal P
Source :: Bioinformation [Bioinformation] 2022 Mar 31; Vol. 18 (3), pp. 80-83. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM.<br />Competing Interests: None declared.<br /> (© 2022 Biomedical Informatics.)